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desvenlafaxine will improve the stage or impact of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Check. Desvenlafaxine inhibits CYP2D6; with greater desvenlafaxine doses (ie, four hundred mg) lessen the CYP2D6 substrate dose by up to fifty%; no dosage adjustment desired with desvenlafaxine doses 7 consecutive times straight awa